Dementia: problem, risks, effects, and management

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I had met my classmate around 4 months back and informed her also about my mom's death. But in a recent email, she wrote to me that I had met her a couple of years back. She also enquired about my mom. Seeing her email, the first thought that came to my mind was: is she suffering from early dementia. I hope not. Maybe, she just forgot about the time that I had met her a few months back. Maybe because it was a hurried and surprise visit.  Nonetheless, dementia is on the rise. It affects people after 60 years of age. The increased life expectancy means that one will see more of such cases in the near future.  India has around 10 million dementia cases out of the world total of 57 million. This is a huge percentage. It affects not only an individual but the whole family. There is this individual who is physically okay but mentally absent. The person needs custodial care and it could turn out to be expensive. It is also emotionally disturbing to see your loved one in that state of...
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MRNA covid-19 vaccine has opened up avenues for renewed interest and enthusiasm of use of mRNA in cancer cure

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 Covid-19 vaccine has arrived amidst a mixed reaction. These vaccines from Pfizer-BioNTech and Moderna are messenger RNA. Another one from German Company CureVac NV is also on its way to be approved. There is more hope in these vaccines beyond control of covid. What are its future benefits?

mRNA vaccines and ordinary vaccines

Most vaccines are inactivated or attenuated viral parts which induce an immune response in the body that offers protection against the virus. They need cell cultures and chemicals. It is time-consuming with risk of contamination. But in case of mRNA, this process is skipped. Scientists determine which protein they want the host body to produce, analyze its amino acid sequence and see what instructions the mRNA must give. The process is faster and the mRNA is safe genetically. 


MRNA and its uses in maladies (Source: Nature)


The history of mRNA and its use

Research into mRNA began in the 1970s. But somehow after a decade of work on it it fell into the background. Money, time, efforts and patience went missing. Also some animal studies also led to fatal inflammation. 

Read here on emotional exhaustion of covid!

But somehow some scientists such as Hungarian-American Katalin Kariko continued work on this front and emerged victorious. She faced a lot of obstacles in her career and had salary cut and demotion. But nonetheless, she did not let her goal and focus to shift. She realized that uridine caused inflammation and changed this in the code with positive results. 

MRNA and cancer cure

Their research was mostly for use of mRNA against cancer. They used it to train the body to make immune cells against the target pathological antigen. This included viruses, other germs and cancer cells. The outcomes of studies in cancer was good and mRNA holds promise in treatment of cancers without affecting normal host cells. 

Not many investors were keen to put in money in this research. But now with the success of the mRNA vaccines against covid-19, renewed interest in them has happened. Hope for cancer cure is in the horizon!!! 


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