The emotionally detached loveless mother!

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Imagine a mother who is physically present but mentally and emotionally absent. This could be due to two factors: 1. Normal mother who hates family or children - this could be a cultural problem, or upbringing problem or an individual level problem  2. Abnormal mother who is emotionally detached and loveless  In both cases, imagine the plight of the family. The husband expects certain help, support and understanding from his wife for family and children. But it is absent. There is sex but no love. The mother is unable to pick up social cues and is selfish. She starts masking techniques and starts blaming husband or family for anything that goes wrong around. She does not understand the protectiveness of her husband and never engages in a proper conversation on it.  She does cooking for family but is not emotionally attached to them. Her children are confused and do not learn anything about social behaviour from her. She uses deception to remain in power but has poor decep...
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MRNA covid-19 vaccine has opened up avenues for renewed interest and enthusiasm of use of mRNA in cancer cure

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 Covid-19 vaccine has arrived amidst a mixed reaction. These vaccines from Pfizer-BioNTech and Moderna are messenger RNA. Another one from German Company CureVac NV is also on its way to be approved. There is more hope in these vaccines beyond control of covid. What are its future benefits?

mRNA vaccines and ordinary vaccines

Most vaccines are inactivated or attenuated viral parts which induce an immune response in the body that offers protection against the virus. They need cell cultures and chemicals. It is time-consuming with risk of contamination. But in case of mRNA, this process is skipped. Scientists determine which protein they want the host body to produce, analyze its amino acid sequence and see what instructions the mRNA must give. The process is faster and the mRNA is safe genetically. 


MRNA and its uses in maladies (Source: Nature)


The history of mRNA and its use

Research into mRNA began in the 1970s. But somehow after a decade of work on it it fell into the background. Money, time, efforts and patience went missing. Also some animal studies also led to fatal inflammation. 

Read here on emotional exhaustion of covid!

But somehow some scientists such as Hungarian-American Katalin Kariko continued work on this front and emerged victorious. She faced a lot of obstacles in her career and had salary cut and demotion. But nonetheless, she did not let her goal and focus to shift. She realized that uridine caused inflammation and changed this in the code with positive results. 

MRNA and cancer cure

Their research was mostly for use of mRNA against cancer. They used it to train the body to make immune cells against the target pathological antigen. This included viruses, other germs and cancer cells. The outcomes of studies in cancer was good and mRNA holds promise in treatment of cancers without affecting normal host cells. 

Not many investors were keen to put in money in this research. But now with the success of the mRNA vaccines against covid-19, renewed interest in them has happened. Hope for cancer cure is in the horizon!!! 


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